RSPCA Queensland has said it could have saved Rufus' life if it had been notified earlier.
The Dogue de Bordeaux was found dumped in a gutter on Coach Rd, Burpengary unable to support his own weight and suffering internal bleeding and kidney failure.
The woman who found Rufus took him to the vet and notified RSPCA.
But RSPCA staff took to Facebook to confirm that they were unable to 'bring him back from the brink' and he had passed away on Thursday afternoon.
"Our hearts are heavy as we shed yet another tear for another unnecessary life lost," RSPCA Queensland posted to Facebook.
"Had poor Rufus been found earlier, he might have pulled through from his awful ordeal. Sadly, the damage was well and truly done.
"He had severe muscle wastage with no strength to stand unassisted, a severe hookworm infestation and renal failure.
"And what continues to be frustrating is that Rufus' condition could have been prevented."
RSPCA Queensland is now calling for information from the public to assist the inspector's investigation.
"We need someone to confirm that he was on that road that day," inspector Sharni Statham said.
"We're just asking anyone who even saw him in that area that day to contact us with a time and location."
Call 1300 264 625 or email firstname.lastname@example.org if you have information.
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